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. 2019 Mar 7;23:75–81. doi: 10.1016/j.molmet.2019.02.011

Figure 3.

Figure 3

Female Pirt deficient mice have an impaired glucose tolerance. Blood glucose traces after an intraperitoneal glucose tolerance test in female chow-fed (A) and high-fat, high-sugar (HFHS) diet-fed (B) and male chow-fed (D) and HFHS diet-fed (E) wild-type (WT) (black) and Pirt−/− (KO) (grey) mice with the corresponding area under the curve (AUC) (C,F) at 26 weeks of age. Phenotyping cohorts with n = 8 per sex, diet, and genotype. Data represent mean ± s.e.m. Data presented in line graphs (A,B,D,E) were analyzed by two-way ANOVA (genotype and time) and data presented in bar graphs (C,F) were analyzed by two-way ANOVA (genotype and diet) comparing WT with Pirt−/− mice. ANOVA was followed by Bonferroni post hoc multiple comparison analysis to determine statistical significance. *P < 0.05, **P < 0.01 effects of genotype within the diets and $$P < 0.01 main effects of genotype irrespective of diet.