Figure 4.

Effects of apigenin on compound 48/80 itch in mice. Five mice each were placed into four groups: Compound 48/80 negative control; compound 48/80 positive control; compound 48/80 with apigenin 75 mg/kg treatment; and compound 48/80 with apigenin 150 mg/kg treatment. Compound 48/80 (50 μg/site, 0.1 mL each) was injected into the dorsal dermis of the mice neck 60 min after administration of 2% geletin or apigenin at indicated concentrations. The number of scratches were monitored with micro-cameras for 30 min and counted in a double-blinded manner. Data are presented as the mean ± SEM of five mice per group. Bars with different small case letters indicated statistically significant difference at p < 0.05.