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. 2019 Mar 27;20(7):1541. doi: 10.3390/ijms20071541

Figure 2.

Figure 2

Adiponectin suppressed NGFβ-induced neurite outgrowth and cell swelling. (A,B) PC12 cells were treated with increasing concentration of NGFβ either in the presence or absence of full-length adiponectin (fADPN, 1 µg/mL) and globular adiponectin (gADPN, 1 µg/mL). Representative results of the cells (arrowhead: neurite) are shown in A and results (percentage of the cells with axon) from five independent experiments are summarized in B. (C,D) PC12 cells were treated with NGFβ (1 ng/mL) either in the presence or absence of full length adiponectin and globular adiponectin (0.1 and 1 g/mL). The ratio of the cell with axon (C) and the changes in cell body size (D) are determined and summarized from three independent experiments. * indicates the statistically significant difference (p < 0.05) from NGFβ treatment alone (Cont).