Figure 3.

(A) Representative photomicrographs (200×) of renal lesions after HES staining in mice 72 h following the intraperitoneal injection of 2, 7.5 and 10 mg/kg F or 2, 4 and 5 mg/kg UN. The sharp symbol (#) indicates mild coagulative necrosis of the tubular epithelium. Affected tubule lumens are filled with hypereosinophilic granular debris. The dollar symbol ($) indicates tubular regeneration with basophilic tubules. The asterisk (*) shows interstitial fibrosis and inflammation, as revealed by saffron coloration. (B) The renal lesion scores and (C) the percentage of tubular and interstitial injuries (tubular necrosis, basophilic tubules, interstitial inflammation and interstitial fibrosis) in kidneys 72 h after the intraperitoneal injection of 0, 2, 5, 7.5 and 10 mg/kg F or 0, 2, 4 and 5 mg/kg UN. The results are presented as the mean ± standard error of the mean. The asterisk represents a significant difference between the treated (n = 6 to 12) and control (n = 11) groups (Holm-Sidak test, * p < 0.05, ** p < 0.005, *** p < 0.001).