Figure 2.

Schematic representation of the advantages of scaffold degradability with regards to restoration of “healthier” tissue engineered urethral replacement. Non-degradable biocompatible scaffolds have lead to several undesirable outcomes like shortenig of the implant, calcification, and narrowing of the urethra, collectively kown as “non-functional remodeling”. On the other hand, resulting regrown tissues following implantation of optimized degradable constructs has lead to “constructive remodeling” with the resulting tissues closer to the native normal urethra.