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. 2019 Apr 3;24(7):1303. doi: 10.3390/molecules24071303

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transmission electron microscopic imaging of Lipofectamine LTX/mRNA LNPs. Two LNP formulations were prepared by mixing mRNA with (a–c) minimal or (d–g) maximal volume of lipofectamine LTX solution that the manufactures suggest to use ((a–c) Lipo-Min and (d–g) Lipo-Max). (a–c) Lipo-Min loaded with (a) 5 PEG-OligoRNAs/mRNA, (b) 10 PEG-OligoRNAs/mRNA, and (c) 20 PEG-OligoRNAs/mRNA. (d–g) Lipo-Max loaded with (d) unhybridized mRNA, (e) 5 PEG-OligoRNAs/mRNA, (f) 10 PEG-OligoRNAs/mRNA, and (g) 20 PEG-OligoRNAs/mRNA. Dotted circle showed large particles prepared through association of several smaller particles. Scale bars: 100 nm.