Figure 2.

Diagram of the domain composition of S. cerevisiae MKPs Msg5, and Sdp1. Msg5-L corresponds to the long translational isoform of Msg5 and Msg5-S to the shorter one. The docking (D)-domain, IYT-motif, and phosphatase domain are drawn in green, purple, and red, respectively. The active site is represented in black and, inside this signature, the essential catalytic cysteine residue is labelled with a red star. The disulfide bond between the non-catalytic cysteine residue within the active site and its upstream cysteine partner is illustrated in blue. The target MAPKs are represented in green or purple, depending on the docking site involved in the binding.