Table 3.
The top-10 deregulated genes in TLR2-CCS versus CTR.
| Gene Symbol | Name | Gene Expression ‡ | Log2FC | Adjusted p Value |
|---|---|---|---|---|
| upregulated | ||||
| IFI44 | Interferon-induced protein 44 | 0.90 | 0.86 | **** |
| ISG15 | Interferon-stimulated gene 15 | 25.01 | 0.84 | **** |
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | 2.05 | 0.79 | **** |
| IFI6 | Interferon alpha-inducible protein 6 | 14.49 | 0.68 | **** |
| HERC6 | Probable E3 ubiquitin-protein ligase HERC6 | 1.24 | 0.53 | **** |
| IRF7 | Interferon regulatory factor 7 | 13.80 | 0.49 | **** |
| H1F0 | Histone H1.0 | 21.75 | 0.47 | **** |
| MX2 | Interferon-induced GTP-binding protein Mx2 | 0.79 | 0.47 | **** |
| ARRDC3 | Arrestin domain-containing protein 3 | 3.42 | 0.46 | **** |
| OAS3 | 2′-5′-oligoadenylate synthase 3 | 0.07 | 0.45 | **** |
| downregulated | ||||
| IL18R1 | Interleukin-18 receptor 1 | 26.24 | −0.44 | **** |
| ZNF850 | Zinc finger protein 850 | 1.10 | −0.37 | ** |
| PDE5A | cGMP-specific 3′,5′-cyclic phosphodiesterase | 0.98 | −0.36 | ** |
| SCAI | Protein SCAI | 1.75 | −0.35 | *** |
| ENSG00000140181 | N/A | 5.13 | −0.34 | *** |
| APAF1 | Apoptotic protease-activating factor 1 | 4.32 | −0.33 | ** |
| JUN | Transcription factor AP-1 | 16.81 | −0.33 | ** |
| RYR3 | Ryanodine receptor 3 | 5.47 | −0.33 | **** |
| PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | 17.85 | −0.31 | **** |
| TXLNB | Beta-taxilin | 2.86 | −0.31 | * |
‡ RPKM (Reads Per Kilobase Million) of control MCs. * p ≤ 0.05; ** p ≤ 0.01; p ≤ 0.001; **** p ≤ 0.0001.