Table 3.
The relative potential targets induced by lignans in S. chinensis.
| Target Gene | Pathway | Relative Target | Relative Pathway | Effective Constituents |
|---|---|---|---|---|
| AChE | Cholinergic synapse | APP | amyloid precursor protein metabolism | Gomisin K; Gomisin G |
| iNOS | Arginine and proline metabolism | Neurotransmitter; Calmodulin; IL | Nitric oxide anabolism; calmodulin binding; neurotransmitter metabolism; inflammatory response | Gomisin K |
| PTGS1 | Arachidonic acid metabolism | PGs | Platelet activation; Cytochrome P450 - arranged by substrate type | Gomisin K |
| PTGS2 | Arachidonic acid metabolism | PGs | inflammatory response; Cytokine signaling in immune system | Gomisin K; Benzoylgomisin H; Schisandrol B; Gomisin D |
| GSK3β | PI3K-Akt signaling pathway; Wnt signaling pathway | Tau; DA | MAPK signaling pathway; Dopaminergic synapse; neurofibrillary tangles | Gomisin K |
| TGFB1 | MAPK signaling pathway | TNF-α | TNF signaling pathway | Schisandrin B |
| MAPK1 | MAPK signaling pathway | Glu; ACh; 5-HT | Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse | Schisandrin B |
| MAPK3 | MAPK signaling pathway | Glu; ACh; 5-HT | Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse | Schisandrin B |
| TBXAS1 | Cytochrome P450 - arranged by substrate type | AA | Arachidonic acid metabolism; Platelet activation | Schisandrin B |
| CYP3A4 | Drug metabolism - cytochrome P450 | Cholesterol; LA; Retinoate | Steroid hormone biosynthesis; Linoleic acid metabolism; Retinol metabolism | Schisandrin B |
| PPARG | PPAR signaling pathway | 9-CRA | Lipid metabolism; Antioxidant system |
Gomisin K |
| TOP2 | Metabolism of proteins | / | Cell cycle | Gomisin K; Angeloylgomisin Q; Benzoylgomisin H; Schisandrol B; Gomisin D; Gomisin G |
| Mir34a | MicroRNAs in cancer | Cyclin-dependent kinase 6 |
Cell cycle | Schisandrin B |
| CCND1 | Cyclins and cell cycle regulation | / | / | Schisandrin B |
| GSR | Glutathione metabolism | GSH | Glutathione metabolism; Antioxidant system |
Schisandrin B |
| NFE2L2 | Protein processing in endoplasmic reticulum | HMOX1 | Porphyrin and chlorophyll metabolism | Schisandrin B; Deoxyschizandrin |
| HMOX1 | Porphyrin and chlorophyll metabolism | APP; IL-10; NFE2L2 | amyloid precursor protein metabolism; Protein processing in endoplasmic reticulum;Cytokine signaling in immune system | Schisandrin |