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. 2019 Feb 20;23:60–74. doi: 10.1016/j.molmet.2019.02.004

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

AKT3 does not compensate for AKT1 in BAT development. (A) Body weight and fat weights of Akt3−/− (n = 9), Akt3−/−;Akt1^myf5cKO (n = 12) and littermate controls (Akt1 floxed) (n = 3) at 6 weeks old (one-way ANOVA). (B) Representative H&E images of the indicated fat depots of Akt3−/−, Akt3−/−;Akt1^myf5cKO and littermate controls (Akt1 floxed) at 6 weeks old (n = 3–4). (C) Western blots of the iBAT of Akt3−/−, Akt3−/−;Akt1^myf5cKO and littermate controls (Akt1 floxed) at 6 weeks old.