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. 2019 Apr 3;20(7):1647. doi: 10.3390/ijms20071647

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of AICAR on the AMPK/mTOR-dependent pathway in 22Rv1 prostate cancer cells. Cells were treated with different concentrations of AICAR for 2 h. The expression of (A) phospho-AMPK, AMPK, (B) TSC1 and TSC2 was examined by western blot. Cells were treated with different concentrations of AICAR for 6 h. (C) The expression of mTOR, cMYC, phosphor-p70S6K and p70S6K was determined by western blot. Actin was used as a loading control in western blot. The western blotting results are representative of results obtained in three separate experiments. (D) Proposed mechanism of the anticancer effects induced by AICAR in 22Rv1 prostate cancer cells.