Table 2.

−ΔCq values for the selected miRNAs and MOR signal score.

ID	MOR−UP miRNAs				MOR−DOWN miRNAs				MOR Signal Score	Average ΔVAS	Dose Ratio	SAE
	hsa-let-7f-5p	hsa-let-7a-5p	hsa-miR-423-3p	hsa-miR-26a-5p	hsa-miR-144-3p	hsa-miR-451a	hsa-miR-215	hsa-miR-363-3p
#1	−2.7	−0.3	−1.0	0.2	−2.8	5.0	−5.6	−3.5	3.0	4.3	1:5
#2	−1.7	0.9	−1.3	0.4	−2.0	5.4	−5.0	−2.9	2.7	4.3	1:8
#3	−2.0	0.3	−0.9	0.1	−1.9	5.7	−5.1	−3.5	2.2	2.7	1:5
#4	−2.3	0.2	−1.3	−0.3	−2.1	5.2	−5.1	−3.3	1.6	−1.0	1:8
#5	−2.5	−0.1	−1.3	0.2	−2.0	5.8	−4.7	−3.2	0.5	1.7	1:8
#6	−2.0	0.2	−0.9	0.0	−1.6	5.7	−4.1	−2.4	−0.2	1.7	1:8
#7	−1.9	0.4	−1.3	0.2	−1.6	5.9	−2.7	−3.3	−0.9	6.0	1:8
#8	−2.1	0.1	−1.1	0.3	−0.6	6.3	−4.4	−2.8	−1.2	6.7	1:5
#9	−1.3	0.5	−1.8	0.1	−1.3	6.6	−3.6	−2.4	−1.9	NA	1:8	+
#10	−2.5	0.0	−1.2	−0.2	−1.3	5.8	−3.1	−2.8	−2.4	1.0	1:5
#11	−2.1	0.5	−1.9	0.2	−0.4	6.5	−4.1	−2.7	−2.7	2.3	1:5	+
#12	−2.3	0.1	−1.5	−0.4	−1.0	6.2	−4.0	−2.5	−2.9	9.4	1:5	+
#13	−1.9	−0.2	−1.8	−0.2	−0.5	7.0	−5.1	−2.5	−3.0	0.7	1:5
#14	−1.5	1.0	−1.7	−0.1	−0.1	6.8	−2.4	−3.1	−3.3	2.7	1:8
#15	−1.9	0.8	−2.2	−0.4	0.0	7.0	−4.9	−2.4	−3.4	0.3	1:8
#16	−2.6	0.0	−2.1	−0.4	−1.2	6.1	−4.0	−2.5	−3.4	0.0	1:8
#17	−3.1	0.0	−1.1	−0.2	−1.5	5.7	−0.9	−3.1	−4.7	NA	1:5	+
#18	−2.5	−0.1	−1.4	−0.3	−0.6	6.4	−3.6	−1.6	−4.9	−13.0	1:8
#19	−2.5	0.1	−1.9	−0.5	0.0	6.2	−3.3	−2.2	−5.4	−1.3	1:5
#20	−2.6	0.2	−2.2	−0.5	0.1	7.5	−3.4	−2.1	−7.2	−0.3	1:8
#21	−2.7	−0.3	−1.5	−0.6	0.2	7.4	−3.5	−1.8	−7.6	7.3	1:5
#22	−2.7	0.7	−2.4	−0.7	−0.1	7.6	−2.1	−1.6	−8.8	−2.0	1:8
#23	−2.5	0.1	−2.5	−1.2	0.4	7.4	−3.4	−1.1	−9.4	0.0	1:8
#24	−3.8	−0.1	−3.6	−1.7	−0.4	7.2	−3.9	−2.5	−9.7	0.0	1:5
#25	−3.8	−1.2	−2.4	−3.2	1.5	8.2	−3.3	−0.6	−16.4	−1.7	1:5

Negative ΔCq values for the selected eight miRNAs, average ΔVAS scores, and MOR signal scores are presented. MOR signal score is calculated by the subtraction of ∑(ΔCq of MOR-UP miRNAs) from ∑(ΔCq of MOR-DOWN miRNAs). The data are sorted by MOR signal score. NA, data not available. Note that plasma miRNA levels are higher when −ΔCq values are higher. SAE, severe adverse event.