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The mechanism of hepatic fibrosis: progression and regression steps. Legend: PDGF: Platelet-derived growth factor; TGBβ: Transforming growth factor β; TNF: Tumor necrosis factor; IL-1β: Interleukin, HSC: Hepatic stellate cell; TRAIL: Related apoptosis-inducing ligand receptor; MMP: Metalloproteinase; ECM: Extracellular matrix. Adapted from: Trautwein C et al., Journal of Hepatology 2015.
