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Inhibitory effects of selected compounds against DNA gyrase and topoisomerase IV.
| Compd. | IC50 (µg/mL) | |
|---|---|---|
| Gyrase a | Topo IV b | |
|
4d
4k |
13.5 25.7 |
24.2 33.1 |
| CIP c | 0.25 | 6.9 |
a Topoisomerase II supercoiling activity; b Topoisomerase IV decatenation activity. c Ciprofloxacin.
