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. 2019 Apr 9;24(7):1386. doi: 10.3390/molecules24071386

Table 1.

Optimization of the reaction conditions.

graphic file with name molecules-24-01386-i001.jpg

Entry Base Solvent Temperature Time (Hours) Yield (%)
1 KOH MeOH Reflux 12 65
2 KOH EtOH Reflux 12 60
3 KOH Water Reflux 16 nr
4 KOH n-BuOH 115 12 92
5 KOH PG 115 12 62
6 NaOH n-BuOH 115 12 85
7 DBU n-BuOH 100 20 nr
8 TEA n-BuOH 100 24 nr
9 a K2CO3 n-BuOH 115 12 22
10 DIPEA n-BuOH 115 24 nr
11 t-BuOK n-BuOH 115 20 - b

nr = no reaction, a K2CO3: potassium carbonate, b dehydration products (anhydroluteins).