. 2019 Apr 9;24(7):1386. doi: 10.3390/molecules24071386

Table 1.

Optimization of the reaction conditions.

Entry	Base	Solvent	Temperature	Time (Hours)	Yield (%)
1	KOH	MeOH	Reflux	12	65
2	KOH	EtOH	Reflux	12	60
3	KOH	Water	Reflux	16	nr
4	KOH	n-BuOH	115	12	92
5	KOH	PG	115	12	62
6	NaOH	n-BuOH	115	12	85
7	DBU	n-BuOH	100	20	nr
8	TEA	n-BuOH	100	24	nr
9	^a K₂CO₃	n-BuOH	115	12	22
10	DIPEA	n-BuOH	115	24	nr
11	t-BuOK	n-BuOH	115	20	- ^b

nr = no reaction, ^a K₂CO₃: potassium carbonate, ^b dehydration products (anhydroluteins).