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. 2019 Mar 31;20(7):1605. doi: 10.3390/ijms20071605

Table 1.

IC50 values (µM) for inhibition of different HDAC isoforms.

HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 Selectivity Reference
SAHA 0.0013 0.0016 0.005 _ 3.6 0.0016 _ 0.48 _ 1,2,3,6,8 [11]
Crebinostat 0.0007 0.001 0.002 _ _ 0.009 _ _ _ 1,2,3,6 [12]
CI-994 0.05 0.19 0.55 _ _ _ _ _ _ 1,2,3 [13]
Cpd-60 0.001 0.008 0.458 _ _ _ _ _ _ 1,2 [14]
BG-45 2 2.2 0.289 _ _ >20 _ _ _ 3 [15]
Tubacin 0.028 0.042 0.275 17 1.5 0.016 8.5 0.17 _ 6 [16]
Tubastatin A 3.2 3.5 4.9 _ _ 0.018 _ _ _ 6 [17]
ACY-738 0.094 0.128 0.218 _ _ 0.0017 _ _ _ 6 [18]
ACY-775 2.123 2.57 1.12 _ _ 0.0075 _ _ _ 6 [18]
ACY-1215 0.058 0.048 0.051 7 5 0.004 1.4 0.1 10 6 [19]
Bavarostat >1000 >1000 >1000 11.3 19 0.06 4.7 8.5 5.2 6 [20]
PCI-34051 >50 >50 6.8 _ _ 2.9 _ 0.01 >50 8 [21]