Table 1.
HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | Selectivity | Reference | |
---|---|---|---|---|---|---|---|---|---|---|---|
SAHA | 0.0013 | 0.0016 | 0.005 | _ | 3.6 | 0.0016 | _ | 0.48 | _ | 1,2,3,6,8 | [11] |
Crebinostat | 0.0007 | 0.001 | 0.002 | _ | _ | 0.009 | _ | _ | _ | 1,2,3,6 | [12] |
CI-994 | 0.05 | 0.19 | 0.55 | _ | _ | _ | _ | _ | _ | 1,2,3 | [13] |
Cpd-60 | 0.001 | 0.008 | 0.458 | _ | _ | _ | _ | _ | _ | 1,2 | [14] |
BG-45 | 2 | 2.2 | 0.289 | _ | _ | >20 | _ | _ | _ | 3 | [15] |
Tubacin | 0.028 | 0.042 | 0.275 | 17 | 1.5 | 0.016 | 8.5 | 0.17 | _ | 6 | [16] |
Tubastatin A | 3.2 | 3.5 | 4.9 | _ | _ | 0.018 | _ | _ | _ | 6 | [17] |
ACY-738 | 0.094 | 0.128 | 0.218 | _ | _ | 0.0017 | _ | _ | _ | 6 | [18] |
ACY-775 | 2.123 | 2.57 | 1.12 | _ | _ | 0.0075 | _ | _ | _ | 6 | [18] |
ACY-1215 | 0.058 | 0.048 | 0.051 | 7 | 5 | 0.004 | 1.4 | 0.1 | 10 | 6 | [19] |
Bavarostat | >1000 | >1000 | >1000 | 11.3 | 19 | 0.06 | 4.7 | 8.5 | 5.2 | 6 | [20] |
PCI-34051 | >50 | >50 | 6.8 | _ | _ | 2.9 | _ | 0.01 | >50 | 8 | [21] |