Skip to main content
. 2019 Feb 20;23:14–23. doi: 10.1016/j.molmet.2019.02.003

Figure 2.

Figure 2

Deficiency of MLKL ameliorates obesity-induced insulin resistance and glucose intolerance. Mice were fed a HFD beginning at 6–8 weeks of age. Measurements were performed during the course of the HFD, as shown below. (A) Total body weight (n = 10 in each group). AUC, area under the curve. (B) Food intake (n = 6 for WT, n = 5 for MLKL−/−). (C) Ratio of organ weight (n = 6 for WT, n = 5 for MLKL−/−). Panc: pancreas. (D and E) GTT (n = 7 for WT, n = 8 for MLKL−/−) (D) and ITT (n = 8 for WT, n = 9 for MLKL−/−) (E), performed after 8 weeks of HFD. (F and G) GTT (n = 7 for WT, n = 8 for MLKL−/−) (F) and ITT (n = 12 for WT, n = 10 for MLKL−/−) (G), performed after 16 weeks of HFD. (H and I) Blood glucose levels of mice fed a HFD for 8 weeks (n = 13 for WT, n = 8 for MLKL−/−) (H), or for 16 weeks (n = 15 for WT, n = 8 for MLKL−/−) (I). (J) Blood insulin levels of mice fed a HFD for 16 weeks during GTT (n = 5 for WT, n = 7 for MLKL−/−). (K) HOMA-IR (n = 5 for WT, n = 7 for MLKL−/−). Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. 2-way ANOVA or Student's t-test were used.