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. 2019 Feb 20;23:14–23. doi: 10.1016/j.molmet.2019.02.003

Figure 4.

Figure 4

MLKL regulates insulin-stimulated PI(3,4,5)P3 production. (A and B) Protein levels of MLKL in HepG2 cells transfected with empty or MLKL overexpressing vectors were determined by western blot (A). PI(3,4,5)P3 levels were determined by immunofluorescence (B). Scale bars, 50 μm. (C and D) Protein levels of MLKL in primary hepatocytes isolated from MLKL−/− mice and WT littermates (C). PI(3,4,5)P3 levels were determined by immunofluorescence (D). Scale bars, 20 μm. Images are representative of three independent experiments.