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. Author manuscript; available in PMC: 2019 Sep 14.
Published in final edited form as: ACS Infect Dis. 2018 Jun 25;4(9):1368–1376. doi: 10.1021/acsinfecdis.8b00103

Table 2.

1,4-Disubstituted 2-AI Meta-Ureas Potentiation of Colistin Against Three A. baumannii Strains

Compd A. baumannii 5075 A. baumannii 19606 A. baumannii 17978
MIC
(μM)		 Concentration
Tested (μM)		 Colistin
MIC
(ng/mL)		 MIC
(μM)		 Concentration
Tested (μM)		 Colistin
MIC
(ng/mL)		 MIC
(μM)		 Concentration
Tested (μM)		 Colistin
MIC
(ng/mL)
Colistin 1000 1000 1000
12a 50 15 ≤ 3.9 15 7.5 62.5 50 15 ≤ 15.6
12b 100 30 ≤ 0.98 50 15 ≤ 3.9 100 30 ≤ 0.98
12c >200 30 15.6 200 30 3.9 50 15 125
12d 200 30 ≤ 0.98 >200 30 ≤ 0.98 >200 30 ≤ 7.8
12e >200 30 ≤ 0.98 >200 30 ≤ 0.98 >200 30 ≤ 7.8
12f >200 30 500 >200 30 125 200 30 250
12g >200 30 500 >200 30 500 >200 30 500
12h 200 30 1.95 200 30 ≤ 1.95 100 30 15.6
12i >200 30 3.9 200 30 ≤ 0.98 >200 30 7.8
12j >200 30 250 >200 30 250 >200 30 250
12k 200 30 ≤ 3.9 >200 30 ≤ 0.98 >200 30 ≤ 15.6