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The ZZ domain of p300 binds to histone H3 and directs the HAT specificity of p300 toward H3K18 and H3K27. (a) A ribbon diagram of the complex (pdb 6DS6) between the p300 ZZ domain (light orange) and histone H3 tail (residues 1–6) (light green). (b) A schematic diagram for the regulation of the p300 HAT activity by the ZZ domain and bromodomain. Dashed line indicates interaction of bromodomain with acetylated histones (see color version of this figure at www.tandfonline.com/ibmg).
