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. 2019 Apr 6;20(7):1713. doi: 10.3390/ijms20071713

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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pH and concentration dependencies of IEM-2163 and IEM-2195 action. (A) Peak current inhibition was pH-dependent, the effects of both drugs disappeared under strong acidification. (B) IEM-2163 and IEM-2195 caused acidic shift of the ASIC3 activation curve. (C–F) Concentration dependencies of IEM-2163 (D,F) and IEM-2195 (C,E) action on peak (C,D) and sustained (E,F) currents. Fitting is shown in solid lines. Note that the concentration dependence of IEM-2163’s action on sustained current was biphasic at pH 6.0 where the current inhibition was small. Low concentrations caused inhibition, but at high concentrations the effect was inverted.