Table 1.

miRNAs associated with sensitivity or resistance to lung cancer therapies.

Chemo-sensitive			Chemo-resistant
miRNA	Target/pathway	Ref.	miRNA	Target/pathway	Ref.
let-7	LIN28	[112]	miR-15b	PEBP4	[110]
miR-7	EGFR	[113]	miR-21	PTEN, SMAD7	[114,115]
miR-17, 20a, 20b	TGFβR2	[116]
miR-17 and miR-92 family	CDKN1A, RAD21	[117]	miR-27a	RKIP	[111]
miR-34a	PEBP4	[118]	miR-92a	PTEN	[119]
miR-101	ROCK2	[120]	miR-106a	?	[121]
miR-106b	PKD2	[107]
miR-135b	FZD1	[122]	miR-181c	WIF1, Wnt/β-catenin pathway	[123]
			miR-196	up-regulation of MDR1, MRP1, ERCC1, Survivin and Bcl-2	[109]
miR-137	NUCKS1	[124]	miR-205	PTEN, Mcl-1 and Survivin	[125,126]
miR-138	ZEB2	[127]	miR-488	eIF3a-mediated NER signaling pathway	[128]
miR-146a	CCNJ	[129]
miR-181b	TGFβR1/Smad signaling pathway	[130]
miR-184	Bcl-2	[131]
miR-218	RUNX2	[132]
mir-296	CX3CR1	[133]
miR-379	EIF4G2	[134]
miR-451	c-Myc-survivin/rad-51 signaling	[135]
miR-503	Down-regulation of MDR1, MRP1, ERCC1, Survivin and Bcl-2	[108]
miR-9600	STAT3	[136]
Radio-sensitive			Radio-resistant
miRNA	Target/pathway	Ref.	MiRNA	Target/pathway	Ref.
miR-29c	Bcl-2, Mcl-1	[137]	miR-21	PTEN, HIF1α, PDCD4	[114,138]
miR-138	SENP1	[139]	miR-25	BTG2	[140]
miR-200c	PRDX2, GAPB/Nrf2, and SESN1	[141]	miR-210	HIF1	[142]
miR-328	γ-H2AX	[143]	miR-1323	PRKDC	[144]
miR-449a	?	[145]
miR-451	c-Myc-survivin/rad-51 signaling	[135]
EGFR TKI-sensitive			EGFR TKI-resistant
miRNA	Target/pathway	Ref.	miRNA	Target/pathway	Ref.
miR-126	Akt and ERK pathways	[146]	miR-21	PTEN, PDCD4	[147]
miR-134/miR-487b/miR-655 cluster	MAGI2	[148]	miR-23a	PTEN/PI3K/Akt pathway	[149]
miR-200c	PI3K/Akt pathway	[150]	miR-30 family	PI3K-SIAH2	[151]
miR-223	IGF1R/PI3K/Akt pathway	[152]	miR-214	PTEN/AKT pathway	[153]
miR-483-3p	integrin β3/ FAK/Erk pathway	[154]
ALK TKI-sensitive			ALK TKI-resistant
miRNA	Target/pathway	Ref.	miRNA	Target/pathway	Ref.
miR-200c	ZEB1	[155]