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. 2019 Mar 27;20(7):1527. doi: 10.3390/ijms20071527

Figure 4.

Figure 4

Effect of I-BET-151 on mitochondrial functions. Oxygen consumption rate of permeabilized ventricular fibers with 10 mM glutamate and 4 mM malate, 0.1 mM ADP, 2 mM ADP, 1 mM pyruvate and 15 mM succinate, and after addition of 2 mM amytal (A). Citrate synthase activity in left ventricle (B). COX activity in left ventricle (C). Citrate synthase activity in right ventricle (D). COX activity in right ventricle (E). W3: Week 3, 3 weeks of exposure to I-BET-151 or vehicle only; Week 6: 3 weeks of exposure to I-BET-151 or vehicle only followed by 3 weeks of drug wash out. Between four and six rats per group. * p < 0.05 and *** p < 0.001 as compared to control group (at W3 or W6), ¤ p < 0.05 and ¤¤ p < 0.01 “10 mg/kg/day group” as compared to “2 mg/kg/day group” (at W3 or W6), $ p < 0.05 W3 as compared to W6.