Table 2.
Immunohistochemical expression of IRF3, IRF7, STAT1, STAT2, ISG15, MX, PKR and OAS in canine distemper virus (CDV)-infected and control cerebellar tissue.
| IRF3 | IRF7 | STAT1 | STAT2 | ISG15 | MX | OAS | PKR | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDV | + | - | + | - | + | - | + | - | + | - | + | - | + | - | + | - |
| Neurons | + | + | ++ | ++ | + | (+) | ++ | ++ | ++ | + | +++ | + | ++ | ++ | ++ | ++ |
| Purkinje cells | + | (+) | (+) | (+) | + | (+) | ++ | ++ | ++ | + | +++ | - | ++ | ++ | +++ | +++ |
| Granular cells | + | + | ++ | ++ | - | - | - | - | + | - | +++ | - | (+) | (+) | - | - |
| Glial cells | ++ | ++ | ++ | ++ | +++ | + | +++ | ++ | + | - | +++ | - | + | - | ++ | - |
| Endothelial cells | +++ | +++ | (+) | (+) | + | (+) | - | - | ++ | (+) | ++ | (+) | + | + | (+) | - |
| Inflammatory cells | +++ | n.a. | - | n.a. | + | n.a. | - | n.a. | - | n.a. | ++ | n.a. | ++ | n.a. | +++ | n.a. |
+++ = 75–100% positive cells; ++ = 30–75% positive cells; + = 10–30% positive cells; (+) = only single cells positive, <10%; - = no positive cells; n.a. = not applicable.