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. 2019 Apr 7;24(7):1363. doi: 10.3390/molecules24071363

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of Ponatinib on the percentage of cells in the G1 phase and the expression of G1 phase-related proteins. (A) SK-Hep-1 and SNU-423 cells were treated with ponatinib, and cell cycle distribution was analyzed by flow cytometry. The percentages of cells in cell cycle phases were calculated from three independent experiments. (B) Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. (C) The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.