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Effect of ponatinib on the phosphorylation of signaling proteins. (A) Effect of ponatinib on the phosphorylation of Src on Tyr416 and Tyr527. (B–E) Effect of ponatinib on the phosphorylation of Mek, Erk, JNK, c-Jun, p38, Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.
