Table 3.
Dose-response profiles of ponatinib + temsirolimus and ponatinib + rapamycin drug combinations.
| Parameter | SK-Hep-1 | SNU-423 |
|---|---|---|
| IC50-ponatinib (μM) | 0.288 ± 0.044 | 0.553 ± 0.041 |
| IC50-temsirolimus (μM) | 0.341 ± 0.197 | 11.407 ± 0.104 |
| IC50-rapamycin (μM) | 1.718 ± 0.282 | 22.665 ± 0.097 |
| IC50-ponatinib + temsirolimus (μM) | 0.002 ± 0.001 | 0.066 ± 0.009 |
| IC50-ponatinib + rapamycin (μM) | 0.019 ± 0.009 | 0.042 ± 0.007 |
| CI50-ponatinib + temsirolimus | 0.013 | 0.122 |
| CI50-ponatinib + rapamycin | 0.077 | 0.078 |
In treatments, two drugs were used and mixed in a 1:1 molar ratio. The cell proliferation assay was performed using a serial dilution within the indicated concentration range.