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. 2019 Apr 3;20(7):1661. doi: 10.3390/ijms20071661

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Successive administration of IMM-H004 3 times a day for one day protects against Permanent focal cerebral ischemia-induced brain injury in adult rats. (A) The timeline diagram of successive administration of IMM-H004 3 times a day for one day. (B) Representative coronal DWI images, and analysis of infarction area and edema ratio. (C) Statistical analysis of the Zea Longa test scores, Forelimbs-slips, Hanging test scores, and screen test scores. Data are shown as the mean ± SD (n = 10/group). * p < 0.05 vs. model; ** p < 0.01 vs. model; *** p < 0.001 vs. model.