Table 3.

Cytokine production by T cells expanded in stirred-tank bioreactor

Data source	Cytokines secretiona	Day -4		Day 0		Day 4
		CD4+	CD8+	CD4+	CD8+	CD4+	CD8+
This studyb	IFN-γ	46.2–54.2	50.9–62.0	15.6–20.8	20.3–34.8	21.1–31.1	39.8–50.9
	IL-2	64.9–76.7	19.8–39.5	79.8–95.6	77.2–93.8	75.7–95.9	74.5–96.1
	IL-4	4.6–6.5	1.7–3.5	4.2–8.7	10.2–19.9	6.0–9.1	5.2–8.2
Literature	IFN-γ	17–23 [64] 6.7–38.9 [65]	27–37 [64] 20–58.4 [65]	N/A		23-47b [66] 15-41d [67]	42-72b [66] 4–42 [68] 10-41d [67]
	IL-2	60 [64]	25–35 [64]			53-78d [67]	49-97d [67]
	IL-4	0.2–4.9 [65]	0.1–1.6 [65]			19-47c [66]	0-2b [66]

Notes

^aAll data are presented as mean ± standard error of the mean (SEM).

^bData were collected using the T cells isolated from 3 donors.

^cData were collected from a 21-day culture.

^dData were collected from a 14-day culture.