Fig. 6.

Model of the hypoxia-clock signalling axis in glioma. The circadian clock exerts tumour promoting or tumour suppressing qualities that are dependent on cellular types. Tumour suppressive Clock^Loss genes are negatively correlated with HIF-1A target genes (CA9, VEGFA and LDHA) in glioma. Clock^Loss scores are plotted such that each spoke of the circular heatmap represents individual patients that are sorted in descending order. Circular heatmaps for HIF-1A target genes are plotted with patients sorted in descending order of Clock^Loss scores. Spearman’s correlation coefficients between Clock^Loss and individual HIF-1A genes are depicted in the centre of the heatmap