Table 2.
Cox proportional hazards regression analyses on the relationship between hypoxia and ClockLoss or ClockGain on overall survival
| Hazard ratio (95% CI) | P-value | |
|---|---|---|
| Glioma (ClockLoss) | ||
| Low ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score | 7.218 (4.234–12.304) | < 0.0001 |
| High ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score | 3.138 (1.733–5.683) | 0.00016 |
| High ClockLoss and low hypoxia score vs. low ClockLoss and low hypoxia score | 1.114 (0.617–2.014) | 0.72 |
| Pan-kidney (ClockLoss) | ||
| Low ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score | 2.512 (1.732–3.643) | < 0.0001 |
| High ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score | 1.580 (1.094–2.282) | 0.0148 |
| High ClockLoss and low hypoxia score vs. low ClockLoss and low hypoxia score | 0.695 (0.423–1.122) | 0.14 |
| Clear cell renal cell (ClockLoss) | ||
| Low ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score | 1.893 (1.207–2.969) | 0.0054 |
| High ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score | 1.285 (0.761–2.170) | 0.35 |
| High ClockLoss and low hypoxia score vs. low ClockLoss and low hypoxia score | 0.796 (0.479–1.324) | 0.38 |
| Glioma (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 9.210 (6.182–13.721) | < 0.0001 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 1.550 (0.917–2.622) | 0.11 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 3.317 (2.105–5.228) | < 0.0001 |
| Astrocytoma (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 5.684 (2.770–11.662) | < 0.0001 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 1.451 (0.527–3.998) | 0.47 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 2.378 (0.985–5.736) | 0.054 |
| Oligodendroglioma (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 4.085 (1.656–10.068) | 0.0022 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 1.218 (0.439–3.374) | 0.71 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 1.541 (0.581–4.091) | 0.38 |
| Pan-kidney (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 3.079 (2.040–4.646) | < 0.0001 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 1.742 (1.089–2.785) | 0.021 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 2.823 (1.850–4.307) | < 0.0001 |
| Clear cell renal cell (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 1.877 (1.222–2.884) | 0.0041 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 1.189 (0.742–1.908) | 0.47 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 1.630 (1.043–2.546) | 0.032 |
| Lung (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 2.037 (1.327–3.129) | 0.0012 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 1.332 (0.755–2.351) | 0.33 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 1.995 (1.221–3.258) | 0.0058 |
| Pancreas (ClockGain) | ||
| High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 1.976 (1.163–3.357) | 0.012 |
| High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score | 0.852 (0.344–2.110) | 0.73 |
| Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score | 0.893 (0.397–2.009) | 0.79 |
Significant P values are marked in italics
CI confidence interval