Table 2. Primary and secondary outcomes.

	Mean outcome (95% CI)a		Crude intervention- control difference (95% CI); P valueb	Adjusted intervention- control difference (95% CI); P valueb
	Intervention (clusters = 15)	Control (clusters = 15)
Primary outcomes
BODE index score changec	-1.67 (-2.18 to -1.16)	-0.66 (-1.09 to -0.22)	-1.01 (-1.65 to -0.37); 0.003	-0.96 (-1.49 to -0.44); 0.001
COPD controld	66.88% (54.99 to 78.77)	38.20% (22.35 to 54.06)	28.68% (9.68 to 47.67); 0.005	29.03% (12.41 to 45.64); 0.001
Secondary outcome
Quit rate among smokerse	53.90% (34.98 to 72.82)	17.52% (7.36 to 27.69)	36.38% (15.66 to 57.10); 0.002	31.98% (15.42 to 48.54); 0.001
Follow-up adherencef	65.54% (52.64 to 78.44)	25.17% (14.86 to 35.47)	40.38% (24.57 to 56.18); <0.001	40.40% (24.15 to 56.67); <0.001

^aArm-specific mean outcomes and their 95% confidence intervals are calculated from cluster-level mean and/or proportion summary values of outcomes. ^bAll intervention minus control differences (that is, intervention effect estimates) are based on crude and/or covariate-adjusted analysis of cluster-level mean and/or proportion summary values of outcomes. ^cBODE index score change calculated as outcome at 6-month follow-up minus outcome at baseline. ^dCOPD control defined as BODE index ≤ 2 at 6-month follow-up. ^eQuit rate among smokers calculated as smokers who had quit smoking at 6-month follow-up. ^fFollow-up adherence defined as attending ≥4 follow-up visits. All analyses use only complete cases.

BODE = Body mass index, airway Obstruction, Dyspnoea, Exercise capacity. CI = confidence intervals. COPD = chronic obstructive pulmonary disease.