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. 2019 Apr 23;20:9. doi: 10.1186/s12860-019-0188-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Knockdown of CCAT1 reverses drug resistance in 5-FU-resistant colon cancer cell lines. a, c. Apoptosis of HCT 116 or HT-29 cells transfected with pcDNA3.1-CCAT1 were assessed using flow cytometry. b, d. Apoptosis of HCT 116/5-FU or HT-29/5-FU cells transfected with siRNA-CCAT1 were assessed using flow cytometry. Error bars represent the mean ± SD. ^**P < 0.01 compared with the respective NC group