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. 2019 Apr 23;7:111. doi: 10.1186/s40425-019-0591-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — An elevated level of constitutive calcium entry (CE) is relevant for chronic lymphocytic leukemia (CLL) clinical outcome. a- Representative kinetic plots of CE in representative healthy control B cells (n = 8, Ctrl), CE- B-CLL (n = 13) and CE+ B-CLL (n = 17) samples. A Cox regression model of progression free survival was used to dichotomize CLL patients in CE- and CE+ (dash line in the islet). Kaplan-Meier plots showing: b- time to progression free survival; c- time to treatment free survival; and d- lymphocyte doubling time between CE+ and CE- CLL groups. P values are indicated when significant