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. 2019 Apr 23;7:111. doi: 10.1186/s40425-019-0591-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Constitutive calcium entry (CE) is related to STIM1, Orai1 and TRPC1. a/b- The effects of the Orai1 channel inhibitor Syntha(S)66 on CE (a) and on anti-IgM Ca²⁺ response (b) in CE+/IgM+ CLL samples (n = 3). c- siRNA control analysis by FACS. The mean fluorescence intensities (MFI) of representative CE+ transfected B-CLL cells are shown in the upper left corner of each plot for the siRNA control, and in the lower left corner for the specific siRNAs. d- Average time course of CE in siRNA transfected CE+ B-CLL cells (n = 3). P values are indicated when significant