Table 3.
Airway smooth muscle cell-derived chemokines, their target cells and effects
| Chemokine | Target | Effect | Ref |
| IL-8 | Neutrophil | Recruitment, activation↑ | [34] |
| Eosinophil, T cell | Recruitment | ||
| Eotaxin | Eosinophil, T cells, basophil | Recruitment | [23,24,29,34,85,86] |
| Mast cell | Induces growth | ||
| RANTES | Eosinophil, T cells, monocytes | Recruitment | [23,24,29,34] |
| GM-CSF | Eosinophil, mq, monocyte | Recruitment, activation↑, proliferation↑ | [34] |
| Neutrophil | Survival↑ | ||
| MCP | Monocytes, lymphocytes, eosinophil, basophil, | Recruitment, activation↑ | [23,24,29] |
| dendritic cells, NK cells | |||
| mθ | IL-1 secretion↑ | ||
| MIP-1a | Eosinophil, NK, T cells, monocytes, mast cell, basophil | Recruitment, activation↑ | [23,24] |
↑, Increase; GM-CSF, granulocyte/macrophage-colony stimulating factor; IL, interleukin; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; mθ, macrophage; NK, natural killer; RANTES, regulated on activation, normal T cell expressed and secreted.