Table 5.
Airway smooth muscle (ASM) cell-derived arachidonic acid metabolites, their target cells and effects
| Cyclooxygenase product | Target | Effect | Reference |
| PGD | ASM | Contraction | [9,87,88] |
| Goblet cell | Mucous secretion↑ | ||
| PGE | ASM | Contraction, proliferation↓ GM-CSF secretion↓ | [9,52,56] |
| Goblet cell | Mucous secretion↑ | ||
| Mast cell | Secretion↓ | ||
| Eosinophil | Recruitment and survival↓ | ||
| T cell | IL-2 secretion↓ | ||
| PGF | ASM | Contraction | [9,87] |
| Goblet cell | Mucous secretion↑ | ||
| Thromboxane | ASM | Contraction and proliferation↑ | [57,89] |
↑, Increase; ↓, decrease; GM-CSF, granulocyte/macrophage-colony stimulating factor; IL, interleukin; PG = prostaglandin.