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. 2019 Apr 24;21:53. doi: 10.1186/s13058-019-1131-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — IRISOE TNBC tumor cells skew MSCs toward the PGE₂-secreting fibrogenic fate, in vitro. Percentage of MSCs stained with Oil Red (a), Alizarin Red S (b), and PicroSirius (c) in cultures exposed to HME, IRIS291, IRIS293 cells, MDA-231/shCtrl, MDA-231/shIRIS, MDA-468/shCtrl, and MDA-468/shIRIS cell CM. d The secretion of PGE₂ from naïve MSCs (black) or MSCs chemically differentiated to adipogenic, osteogenic, chondrogenic, or fibrogenic fates, before they were exposed to hypoxic HME (blue), hypoxic IRIS291 (orange), hypoxic IRIS292 (yellow), or hypoxic IRIS293 (red) cell CM