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. 2019 Apr 11;24(7):1435. doi: 10.3390/molecules24071435

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Oral administration of HJF improves forelimb-use asymmetry and d-AMPH-induced rotational asymmetry in a mouse model of PD. (A). Cylinder test: 6-OHDA-lesioned mice showed a significant decrease in the percentage of contralateral contacts of a forelimb at 7 days. HJF-treated group showed an increase in the percentage of contralateral contacts compared to that in the vehicle-treated group. * p < 0.05 and ** p < 0.01, one-way ANOVA followed by Tukey’s post hoc test. B and C. D-AMPH-induced rotation test. D-AMPH (5 mg/kg)-induced rotation was tested at 3 weeks after 6-OHDA lesion. The total rotation number was counted for 60 min after d-AMPH administration (B). Time course of the rotations (C). * p < 0.05 and ** p < 0.01, Student’s t-test.