Table 2.
Synthesis of reported findings by lipid MSI in renal cortex and glomerular areas. MALDI: matrix-assisted laser desorption ionization. TOF-SIMS: time of flight–secondary ion mass spectrometry. SP: sphingolipids. GP: glycerophospholipids. SL: sterol lipids.
| Reference | Species | Technology | Pathology/Condition | Main Finding (ion/molecule) | Lipid MAPS Category | Anatomical Region |
|---|---|---|---|---|---|---|
| [30] | mouse | MALDI | Bisphenol toxicity | SM d22/20:4 Cer d18:2/24:1 | SP | Cortex |
| [35] | mouse | MALDI | IgA nephropathy | PC O-16:0/22:6 PC O-18:1/22:6 | GP | Cortex |
| [34] | mouse | MALDI | Diabetic nephropathy | NeuGc-GM3 | SP | Glomeruli |
| [25] | mouse | MALDI | Diabetic nephropathy | SM d18:0/16:0 | SP | Glomeruli |
| [28] | mouse | MALDI | FSGS (doxorubicin injection model) | LPC 16:0 LPC 18:0 |
GP | Glomeruli |
| [33] | mouse | MALDI | Fabry disease model | Gb3; Ga2 | SP | Glomeruli |
| [66] | Human biopsies | TOF-SIMS | Fabry disease | Gb3; Ga2 | SP | Glomeruli |
| [44,45] | mouse | MALDI | normal | PC 32:0 | GP | Cortex |
| [25] | mouse | MALDI | normal | PA 36:1 | GP | Glomeruli |
| [63,64,65] | mouse | TOF-SIMS | normal | Cholesterol | SL | Glomeruli |
| this report | mouse | TOF-SIMS | normal | Cholesterol SM d34:1 |
SL-SP | Glomeruli |