Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 23;15:1744806919842961. doi: 10.1177/1744806919842961

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 5. — NB001 blocked the pre-LTP in the IC of WT mice. (a) Pooled data of fEPSPs slopes show that pre-LTP was totally blocked by 5 μM NB001 in the superficial layers of IC (six slices of six mice). (b) Pooled data of fEPSPs slopes show that pre-LTP was effectively blocked by 5 μM NB001 in the deep layers of IC (six slices of six mice). (c) Sample traces and statistical data show that PPR was not significantly changed during pre-LTP induction with 5 μM NB001. (d) Summarized data show the blocking effect on the induction of pre-LTP with different doses of NB001 from 0.5 to 50 μM. n.s. means no significant difference, Calibration: 50 μV, 10 ms. LTP: long-term potentiation; ATPA: amino-3–(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid; AP5: D(-)-2-amino-5-phosphonopentanoicacid; fEPSP: field excitatory postsynaptic potential.