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. 2019 Apr 23;15:1744806919842958. doi: 10.1177/1744806919842958

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — MMP inhibitors do not affect the maintenance of postsynaptic LTP in the ACC. (a) Effect of bath application of 1 µM GM 6001 on the maintenance of LTP. Top: example traces of eEPSCs before (1) and after (2) GM6001 application. Bottom: a time course plot of pooled data for the eEPSCs in the ACC with bath application of GM 6001 (control group: n = 6 neurons/6 mice, GM 6001 group: n = 5 neurons/5 mice). (b) Effect of bath application of 2 µM UK 356618 on the maintenance of LTP (control group: n = 6 neurons/6 mice, UK 356618 group: n = 5 neurons/5 mice). (c) Effect of bath application of 100 nM MMP-9 inhibitor I on the maintenance of LTP (control group: n = 6 neurons/6 mice, MMP-9 inhibitor I group: n = 5 neurons/5 mice). (d) Effect of bath application of 10 µM SB 3CT on the maintenance of LTP (control group: n = 6 neurons/6 mice, SB 3CT group: n = 5 neurons/5 mice). (e) Summary of the effects of MMP inhibitors on the induction of LTP in the ACC. The mean amplitudes of eEPSCs were determined at 55–60 min after the induction of LTP. eEPSC: evoked excitatory postsynaptic current; MMP: matrix metalloproteinase.