Table 1.
Mouse models of multiple myeloma.
| Model | Features | |
|---|---|---|
| Xenograft models | ||
|
| ||
| SCID | Lack T and B lymphocytes | |
|
| ||
| NOD/SCID | SCID + no circulating complement and low NK cell function | |
|
| ||
| NSG | NOD/SCID + lack IL-2 | |
| (NOD/SCID/IL2Rγnull) | ||
|
| ||
| SCID-hu | SCID implanted with human fetal bone chips | |
|
| ||
| SCID-rab | SCID implanted with rabbit bone chips | |
|
| ||
| SCID-synth-hu | SCID implanted with 3D polymeric scaffolds coated with human BM stromal cells | |
|
| ||
| Immunocompetent models | ||
|
| ||
| 5T series | Syngeneic transplant of cell lines from spontaneously arising MM in aged C57BL/KaLwRij mice[188, 189] | |
| 5T2MM | Moderate, progressive disease course | |
| 5T33MM | Aggressive, rapidly progressive disease course | |
| 5TGM1 | Cell line derived from 5T33MM | |
|
| ||
| Vk*MYC | Transgenic: spontaneous AID-dependent activation of MYC in post germinal B cells[17] | |
| Transplant: syngeneic transplant of plasma cell lines from transgenic Vk*MYC mice | ||
|
| ||
| Myc/Bcl-XL | Bitransgenic offspring of hemizygous Myc transgenic mice and hemizygous Bcl-XL mice[17] | |
|
| ||
| XBP-1 | Eμ-directed expression of XBP-1 spliced isoform, a factor governing plasma cell development that has been reported to frequently be overexpressed in human MM[18] | |
|
| ||
| MOPC315.BM | Syngeneic transplant of plasmacytoma-resembling MM cells from granulomas in Balb/c mice injected intraperitoneally with mineral oil | |