Table 4.
Adipokine and inflammatory biomarker levels at baseline vs. after 2 years of lifestyle modification, according to percentage of weight loss. MHO participants: baseline, n = 115; 3 months, n = 104; 1st year, n = 75; and 2nd year, n = 67.
| Weight loss | Baseline | 3 months | 1 year | 2 years | p (baseline vs. 2 y) | |
|---|---|---|---|---|---|---|
| Adiponectin (ng/ml) | <5% | 7.0 ± 2.1 | 7.1 ± 2.5 | 7.7 ± 3.5 | 5.8 ± 2.4 | 0.003 |
| ≥5-<10% | 7.8 ± 3.0 | 9.0 ± 4.3 | 12.6 ± 5.1 | 6.7 ± 3.1 | 0.699 | |
| ≥10% | 7.7 ± 3.1 | 7.4 ± 3.4 | 12.6 ± 5.5 | 8.6 ± 4.8 | 0.911 | |
| All | 7.4 ± 2.7 | 7.7 ± 3.4 | 10.7 ± 5.2 | 7.05 ± 3.7 | 0.039 | |
|
| ||||||
| Resistin (ng/ml) | <5% | 5.5 ± 2.4 | 4.6 ± 1.2 | 6.1 ± 2.8 | 7.9 ± 3.4 | <0.001 |
| ≥5-<10% | 5.2 ± 2.2 | 5.2 ± 1.6 | 5.5 ± 1.9 | 7.5 ± 4.4 | 0.08 | |
| ≥10% | 5.2 ± 1.8 | 5.8 ± 2.3 | 5.4 ± 1.9 | 8.8 ± 4.3 | <0.001 | |
| All | 5.3 ± 2.2 | 5.1 ± 1.8 | 5.7 ± 2.4 | 8.1 ± 2.9 | <0.001 | |
|
| ||||||
| hsCRP (mg/l) | <5% | 5.4 ± 2.9 | 5.0 ± 2.7 | 4.1 ± 2.1 | 3.3 ± 3.1 | 0.003 |
| ≥5-<10% | 5.2 ± 2.5 | 4.6 ± 2.4 | 3.4 ± 2.4 | 3.2 ± 2.8 | 0.010 | |
| ≥10% | 5.2 ± 2.6 | 4.4 ± 2.3 | 3.8 ± 3.04 | 3.2 ± 3.3 | 0.097 | |
| All | 5.3 ± 2.7 | 4.7 ± 2.5 | 3.8 ± 2.5 | 3.3 ± 3.1 | <0.001 | |
|
| ||||||
| IL-6 (pg/ml) | <5% | 4.9 ± 0.9 | 4.8 ± 1.2 | 7.4 ± 1.9 | 2.5 ± 0.7 | <0.001 |
| ≥5-<10% | 5.1 ± 1.2 | 6.0 ± 2.6 | 6.9 ± 2.0 | 2.5 ± 0.4 | 0.001 | |
| ≥10% | 4.5 ± 0.8 | 5.5 ± 2.7 | 7.5 ± 3.2 | 2.4 ± 0.7 | <0.001 | |
| All | 4.8 ± 1.0 | 5.3 ± 2.2 | 7.3 ± 2.5 | 2.4 ± 0.6 | <0.001 | |
|
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| TNFa (pg/ml) | <5% | 13.3 ± 1.0 | 12.5 ± 1.4 | 11.3 ± 2.7 | 10.9 ± 3.4 | 0.001 |
| ≥5-<10% | 13.6 ± 0.6 | 11.8 ± 2.3 | 11.4 ± 2.1 | 13.8 ± 1.6 | 0.019 | |
| ≥10% | 13.9 ± 2.5 | 12.7 ± 2.7 | 10.4 ± 2.3 | 9.8 ± 0.8 | <0.001 | |
| All | 13.6 ± 1.5 | 12.4 ± 2.1 | 11.0 ± 2.5 | 11.1 ± 2.9 | <0.001 | |
Group 1: weight loss <5% (baseline: 3 months, n = 47; 1st year, n = 20; and 2nd year, n = 23); Group 2: weight loss ≥5-<10% (baseline: 3 months, n = 27; 1st year, n = 27; and 2nd year, n = 22); Group 3: weight loss ≥10% (baseline: 3 months, n = 30; 1st year, n = 28; and 2nd year, n = 22). Normal values (NV): adiponectin NV: 0.8–21; resistin NV: 6.1–26.4; hsCRP NV: 0.07-8.2; IL-6 NV: 3.13–12.5; TNFa NV: <15.6.