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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: DNA Repair (Amst). 2019 Feb 16;76:30–39. doi: 10.1016/j.dnarep.2019.02.005

Figure 2. Human DUBs.

Figure 2.

Human DUBs consist of two classes of enzymes: cysteine proteases and metalloproteases. Cysteine proteases are further subdivided into five families, including ubiquitin-specific proteases (USPs), ubiquitin carboxyl-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph (Josephin) domain containing (MJD) proteases, and MINDY (motif interacting with Ub-containing novel DUB family). The JAB1/MPN/MOV34 domain containing proteases (JAMMs) family is the only representative of the metalloproteases class of DUBs. Adapted from (2).