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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: DNA Repair (Amst). 2019 Feb 16;76:30–39. doi: 10.1016/j.dnarep.2019.02.005

Figure 5. USP7 polyubiquitin cleavage specificity.

Figure 5.

USP7 preferentialy binds free K48 side chains, which directs USP7 to the distal ubiquitin subunit of K48-polyubiquitin and promotes sequential exo-cleavage of K48-linked poly-ubiquitin. Whereas USP7 can bind all subunits of K63-polyubiquitin and promotes exo-, endo-, and base-cleavage. Adapted from (85).