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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: DNA Repair (Amst). 2019 Feb 16;76:30–39. doi: 10.1016/j.dnarep.2019.02.005

Figure 6. Small molecule inhibitors of USP7.

Figure 6.

USP7 inhibitor complexes are overlayed and colored according to the region of the catalytic domain they target. Residues of the catalytic triad is shown as red spheres. The compounds that bind to the catalytic cleft are shown in purple, alosteric inhibitors that bind outside of the catalytic cleft are shown in blue, and those directly targeting the catalytic triad are shown in green. FT827 targers the catalytic cleft and extends to the catalytic triad. P22077, P50429 and FT827 covalently modify catalytic cystein C223. PDB 5UQX was used to display USP7 catalytic domain.