Table 2.
Diagnostic performances of N-13 ammonia positron emission computed tomography-computed tomography and Tc-99m glucoheptonate single photon emission computed tomography-computed tomography
| Modality | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) |
|---|---|---|---|---|---|
| Overall | |||||
| N-13NH3 PET-CT | 78.6% (59.1-91.7) | 88.9% (70.8-97.7) | 88.0% (68.8-97.5) | 80.0% (61.4-92.3) | 83.6% (71.7-91.1) |
| Tc-99m GHA SPECT-CT | 85.7% (67.3-96.0) | 85.2% (66.3-95.8) | 85.7% (67.3-96.0) | 85.2% (66.3-95.8) | 85.5% (73.8-92.4) |
| Low-grade (I and II) | |||||
| N-13NH3 PET-CT | 79.0% (54.4-94.0) | 100% (81.5-100) | 100% (78.2-100) | 81.8% (59.7-94.8) | 89.2% (75.3-95.7) |
| Tc-99m GHA SPECT-CT | 79.0% (54.4-94.0) | 88.9% (65.3-98.6) | 88.2% (63.6-98.5) | 80.0% (56.3-94.3) | 83.8% (68.9-92.4) |
| High-grade (III and IV) | |||||
| N-13NH3 PET-CT | 77.8% (40.0-97.2) | 66.7% (29.9-92.5) | 70.0% (34.8-93.3) | 75.0% (34.9-96.8) | 72.2% (49.1-87.5) |
| Tc-99m GHA SPECT-CT | 100% (66.4-100) | 77.8% (40.0-97.2) | 81.8% (48.2-97.7) | 100% (59.0-100) | 88.9% (67.2-96.9) |
CI: Confidence interval, PPV: Positive predictive value, NPV: Negative predictive value, Tc-99m GHA SPECT-CT: Tc-99m glucoheptonate single photon emission computed tomography-computed tomography, N-13NH3 PET-CT: N-13 ammonia positron emission computed tomography-computed tomography