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. 2019 Apr 23;39(4):BSR20182144. doi: 10.1042/BSR20182144

Figure 2. Desipramine treatment improved endothelium-dependent vascular function in diabetic mice.

Figure 2

Acetylcholine (ACh)‐induced endothelium‐dependent (A) and SNP‐induced endothelium‐independent (B) relaxations of aortic rings from db/db mice treated for 12 weeks with vehicle or desipramine. Chronic treatment with desipramine increased the level of NO in the serum (C) and aortas (D) of db/db mice. (E) NO generation was measured by DAF-FM-DA fluorescence under various treatments. Desipramine treatment increased the level of NO in the aortas of db/db mice. (F) Desipramine treatment increased the level of eNOS phosphorylation in aortas from db/db mice. Data are shown as the mean ± S.E.M. with n=5 animals per group. *P<0.05 compared with the NC group. #P<0.05 compared with the DC group.