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. 2019 Apr 17;9:114. doi: 10.3389/fcimb.2019.00114

Table 7.

Quantification of organic acids after infection assays (Mean ± SD).

Organic acids concentration (g/L)
Acetic acid Lactic acid Propionic acid Succinic acid
Control (Both + Epitelium) 1.314 ± 0.062 0.399 ± 0.386 <LOQ 0.126 ± 0.002
Control A. vaginae 1.117 ± 0.111 0.420 ± 0.525 <LOQ 0.050 ± 0.001
Control G. vaginalis 1.043 ± 0.450 0.516 ± 0.410 <LOQ 0.051 ± 0.001
Control P. acnes 1.203 ± 0.635 0.616 ± 0.497 0.829 ± 0.869a* 0.073 ± 0.036
Control St. agalactiae 1.217 ± 0.246 5.172 ± 0.314a** <LOQ 0.063 ± 0.019
Control BPL005 1.371 ± 0.122 4.769 ± 0.145a** 0.093 ± 0.002a* 0.045 ± 0.001
BPL005 + A. vaginae 1.325 ± 0.103 4.515 ± 0.403b** 0.139 ± 0.005b* 0.048 ± 0.001
BPL005 + G. vaginalis 1.338 ± 0.073 4.392 ± 0.223b** 0.142 ± 0.010b* 0.046 ± 0.003
BPL005 + P. acnes 1.337 ± 0.206 4.160 ± 1.189b** 0.309 ± 0.011 0.067 ± 0.024
BPL005 + St. agalactiae 1.264 ± 0.021 4.800 ± 0.002 <LOQ 0.048 ± 0.002

LOQ, Limit of quantification = 0.01 g/L (lactic acid, succinic acid, propionic acid, butyric acid) and 0.05 g/L (acetic acid). Statistics are done:

a

comparing control (broth + epithelium) vs. control of pathogen, are statistically different;

b

each pathogen control vs. its grown together with strain BPL005, are statistically different.

*

p-value < 0.05

**

p-value < 0.001.